New Delhi: The new generation of weight loss injections – already popular globally – is now showing strong results in Indian patients too. A recent study from a Delhi hospital shows that more than 4 out of 10 people have lost at least 10% of their body weight, with doctors saying this level can significantly improve overall health.The research, conducted by doctors at Max Super Specialty Hospital, Saket led by endocrinologist Dr Ambrish Mithal and published in the Indian Journal of Endocrinology and Metabolism, tracked 150 overweight and obese adults on these treatments in routine clinical practice.On average, patients lost about 8% of their body weight in six months – around 6 to 10 kg for many. Nearly three-quarters lost at least 5%, which is considered minimal for health benefits like better sugar control and reduced heart risk. Experts said the findings are based on short-term follow-up of about six months. Dr. Ambrish Mithal said, “This is not the ultimate weight loss. With longer follow-up, especially one year, the reduction is likely to be much greater.”But the results were not the same for everyone.People without diabetes responded better, and lost about twice as much weight as those with diabetes. Studies suggest that this may be due to profound metabolic changes and insulin resistance in diabetic patients.The type of medicine also matters. Patients taking tirazepate – a new dual-action injection – lost more and faster weight than those taking semaglutide. Many people reach the 10% mark within 9 to 10 months, although doctors caution that this process happens gradually, not immediately.The study also provides a reality check. Younger patients and those who were using these drugs for the first time saw results sooner, while those who had used similar drugs before saw weight loss more slowly.Side effects such as nausea, bloating and constipation were common, especially in the early stages, but were manageable and did not force patients to discontinue treatment.Unlike clinical trials, which are strictly controlled, this study reflects what happens in everyday life – where people may miss doses, change their diet or have other health conditions. Still, the results persisted, leading doctors to believe that these drugs work beyond ideal settings.With obesity and diabetes on the rise in India, the findings suggest there is a need for a change in the approach to weight loss – from just diet and exercise to medical support that can make a measurable difference.Experts said the message is simple: These injections are not a magical solution, but when used consistently and in conjunction with lifestyle changes, they can lead to steady, meaningful weight loss over time.