Mitochondrial fatigue is a lesser known reason behind persistent low energy.

There are days when sleep is complete, food is on time, yet the body aches. The mind slows down and even small tasks seem more burdensome than necessary. This type of fatigue is often attributed to stress or age. But science is indicating otherwise in terms of how well the body produces energy at the cellular level.Inside every cell there are small structures called mitochondria. They convert food and oxygen into useful energy. When this system begins to falter, the result is not dramatic illness, but a steady drain. That persistent low energy has a name: mitochondrial fatigue.

What exactly is Mitochondrial Fatigue?

Dr. Ravindra Srivastava explains it simply, “Most people are always tired despite adequate sleep. The main cause of this persistent fatigue is stress or a busy lifestyle, yet an unknown cause may be mitochondrial fatigue. Mitochondria are tiny structures located within our cells that can be considered powerhouses because they help our body generate the energy needed to perform its functions. When these giants fail to perform effectively, the body will be unable to produce enough energy and will also experience constant fatigue.”To put it bluntly, it’s not like the body is running out of fuel. This is the body struggling to convert fuel into energy efficiently.

It starts at the cellular level, often driven by lifestyle habits. Symptoms are subtle but affect daily life.

Signs people often ignore

This form of fatigue rarely manifests as an overt medical condition. It blends into everyday life, which is why it goes unnoticed.Dr. Srivastava says, “Mitochondrial fatigue does not necessarily manifest clearly and that is why it is usually neglected. Symptoms such as chronic fatigue, brain fog, lack of stamina, muscle weakness and poor concentration are common. Other individuals may also have frequent headaches or feel tired even with light exercise. Such symptoms can impact daily productivity and general quality of life.“These signs often appear gradually. A missed deadline here, a forgotten detail there, or routine tasks requiring more effort, over time, they add up.

What unbalances mitochondria?

Energy production depends on a constant supply of nutrients, oxygen, and rest. When daily habits disrupt that balance, mitochondria feel the stress.Dr. Srivastava explains, “There are many lifestyle factors that can affect the functioning of mitochondria. Unhealthy eating habits, inadequate physical exercise, stress, lack of sleep and too much screen time can reduce the efficiency of energy production in the body. Additionally, pollution and certain medical conditions can also contribute. These factors can ultimately slow down the body’s natural energy system.“research from National Institutes of Health This highlights how oxidative stress damages mitochondrial function over time.These are not sudden changes. They build up slowly, often unnoticed.

Why does modern life make it worse?

The body was designed for cycles, activity and rest, daylight and darkness. Today’s daily routine disrupts that rhythm.Late night scrolling, irregular meals, processed food and constant mental stress create a mismatch between what the body expects and what it gets. Over time, this mismatch affects the way the mitochondria function.The result is not a dramatic illness, but a quiet recession. Drops in energy become the new normal, and people begin to adjust their expectations rather than question the cause.

The solution is not a quick fix, but consistent changes in diet, sleep, activity, and stress management.

Can energy be restored from within?

The exciting thing is that mitochondria are responsive. When circumstances improve, they adapt.Dr. Srivastava explains, “The positive news is that in most cases, mitochondrial health improves with simple lifestyle changes. A healthy diet consisting of fruits, vegetables, and whole foods is a good source of nutrients that are essential for energy production. Exercise such as brisk walking, although it may be so simple, can be used to increase the functioning of cells. It is also important to get 7-8 hours of quality sleep, rest and manage stress by using relaxation strategies, and staying hydrated.“Even small changes matter. A 20-minute walk, consistent bedtime, and balanced meals can begin to reset energy patterns.

Prevention is not complicated, but consistent

There is no single solution. The focus shifts from quick growth to stable habits.Eat foods that are close to their natural formMove daily, even if gentlyPrioritize sleep as a non-negotiable taskReduce frequent screen exposure, especially at nightCreate moments of pause during the dayEnergy drinks and caffeine may provide temporary relief, but they do not fix the underlying process.

The big picture: small changes, lasting impact

Dr. Srivastava puts it clearly, “Instead of using short-term solutions like caffeine or energy drinks, you should think about forming some long-term habits that will keep your body nourished down to the cellular level. If fatigue does not improve even after lifestyle changes, it is advisable to visit a doctor and get checked. Knowledge of mitochondrial fatigue may enable individuals to have greater control over their energy needs and live a more active, healthy lifestyle.“There is a quiet shift that occurs when the energy comes back. Focus is sharpened, mood is stabilized and daily life feels less like effort and more like flow.Medical experts consultedThis article includes expert inputs shared with TOI Health:Dr. Ravindra Srivastava, Senior Consultant – Neurosciences, Shardacare-Healthcity.The input was used to explain how persistent low energy may be linked to underlying mitochondrial function and metabolic imbalances, and to highlight the importance of medical guidance before using supplements or natural alternatives to overcome fatigue.

Nearly a year after the devastating Air India Flight 171 crash took the lives of his wife and two-year-old daughter, a 28-year-old Indian-origin man is now fighting a new battle – to remain in the United Kingdom.Mohammadia Sethwala, originally from Vadodara, Gujarat, was informed by the UK Home Office on April 9 that his application to remain in the country on compassionate grounds had been rejected.Authorities have kept him on immigration bail until April 22 and have directed him to leave Britain after that.Sethwala had moved to the UK in 2022 on a dependent visa to join his wife Sadiqa, who was studying International Business Management.The couple later settled in Rugby, where she had secured employment and was on her way to obtaining a work permit, a move that would have secured their future in Britain.That future was suddenly shattered on June 12, 2025, when an Ahmedabad-London flight crashed moments after takeoff, killing Sadiqa and her baby Fatima.

“I have nothing left”

Recalling his ordeal, Sethwala said that on the day of the accident he was working the morning shift so that he could pick up his family from the airport. Speaking to The Sun, he said: “I thought it would be a different plane… It couldn’t be theirs, but it was.”This tragedy not only took away his family, but also took away his basis for legal stay in Britain. His dependent visa expired earlier this year, and subsequent attempts to secure a new visa or employment sponsorship have failed.Struggling with grief and mental health problems, Sethwala says returning to India is not an option he can bear emotionally. He told The Sun, “I have nothing left… I won’t be able to escape my grief by coming back home. But here I can start to move forward.”

legal battle

Sethwala’s legal team is preparing to challenge the Home Office’s decision in a UK court, seeking to lift the immigration bail order. If successful, this may allow him to apply afresh for the visa.His case has been criticized by activists and migrant rights groups, who argue that leniency should be exercised in exceptional humanitarian circumstances. However, the Home Office has said that all applications are assessed strictly in accordance with existing immigration rules.

A life stopped in the middle of a dream

After returning to India briefly after the accident, Sethwala began rebuilding his life in London with the support of relatives and a close-knit community, friends say.The Air India Flight 171 crash remains one of the deadliest aviation disasters in recent years, killing passengers, crew and people on the ground after the Boeing 787-8 plane crashed into a medical hostel building and burst into flames.

Emily Blunt attends the world premiere of “The Devil Wears Prada 2” at David Geffen Hall on Monday, April 20, 2026 in New York. (Photo by Ivan Agostini/Invision/AP)

Emily (The Devil Wears Prada) may not have looked her best at the Natural History Museum’s annual benefit, but she made up for it at the premiere of ‘The Devil Wears Prada 2’ in New York City. actress emily blunt Turned heads in a sculptural Schiaparelli ball gown with sparkling Mikimoto jewels.Emily Blunt walks the red carpet in a Schiaparelli Haute Couture gown from his Spring/Summer 2026 collection. The sculptural gown featured a fitted raffia bodice with a dramatic, tiered, voluminous ivory tulle skirt, giving it a high-fashion silhouette.

Emily Blunt attends the world premiere of “The Devil Wears Prada 2” at David Geffen Hall on Monday, April 20, 2026 in New York. (Photo by Ivan Agostini/Invision/AP)

According to the designer, 4,000 hours of hard work went into this gown. It contained 25,000 silk feathers. This dress is more like wearable art than a standard red-carpet gown. Schiaparelli’s creative director, Daniel Roseberry, who designed her custom sequin-covered gown at the 2024 Oscars, is the craftsman behind this new piece.

Emily Blunt attends the world premiere of “The Devil Wears Prada 2” at David Geffen Hall on Monday, April 20, 2026 in New York. (Photo by Ivan Agostini/Invision/AP)

For jewelry, Emily Blunt chose Mikimoto. She walked the red carpet at Lincoln Center, soaking pearls. The choker from Mikimoto’s Les Petals Place Vendôme Roses collection was inspired by rose petals dancing in the wind. It contained 156 Akoya cultured pearls. The 18K pink gold choker also featured 4.86-carat diamond petals. The matching bracelet featured three rows of Akoya cultured pearls with a 2.64-carat diamond. Both bracelets were made of 18K white gold and featured a total of 243 additional Akoya cultured pearls. The matching 18K gold earrings featured 0.72 carat diamonds and 7.5 mm Akoya cultured pearls.Speaking to InStyle, Emily Blunt explained how she instantly fell in love with the piece. “As soon as I saw the Mikimoto Les Petales Choker, I immediately fell in love with it – it is a special piece with the most exquisite detail and design. As the originator of cultured pearls, I have long admired the maison and feel truly honored to wear such an extraordinary creation that reflects a remarkable heritage.”Her stylist Jessica Pester said, “We’re seeing a strong resurgence in demand for pearl jewellery, especially jewelery that feels modern in its design. Mikimoto high jewelery perfectly embodies this: exceptional craftsmanship paired with the world’s finest pearls, creating pieces that feel both timeless and fresh. When you wear pearls, it has to be Mikimoto.”

From left, Meryl Streep, Emily Blunt, Stanley Tucci and Anne Hathaway attend the world premiere of “The Devil Wears Prada 2” at David Geffen Hall on Monday, April 20, 2026 in New York. (Photo by Ivan Agostini/Invision/AP)

Emily Blunt chose a sleek updo and bold red lip. Her dramatic look definitely turned heads, including that of her ‘The Devil Wears Prada 2’ co-star Anne Hathaway.

JKBOSE 10th class summer zone results declared

JKBOSE 10th Result 2026: : Jammu and Kashmir Board of School Education (JKBOSE) declared the Class 10th Result 2026 for Summer Zone Jammu Division on April 21, 2026 at 11 am.Students who appeared in the annual examinations can now access their scorecard through the official portals jkeresults.nic.in and jkbose.jk.gov.in by using the roll number and registration number.Access to results through official portalThe scorecards are available on jkresults.nic.in and jkbose.jk.gov.in where candidates need to enter the roll number and registration number printed on the admit card to view the detailed marksheet.To download the result, students have to select the Class 10 Summer Zone link, submit the credentials and download the PDF copy for future use and printing.An SMS facility is available for students facing connectivity issues, for which they need to type JKBOSE10 followed by roll number and send it to 5676750.The online marksheet contains student name, father’s name, roll number, registration number, subject-wise theory and practical marks, total marks and qualifying status.If discrepancies are found in personal details, students are directed to contact their school principal for correction and verification.After downloading the result, students are advised to save digital copies, print multiple copies and prepare documents for admission to higher secondary classes.Revaluation and checking applications will be opened through a separate notification, allowing students to request re-checking of answer sheets for specific subjects.JKBOSE has confirmed that all information and services remain available through the official websites, with SMS access provided to manage high traffic periods.• Direct link to check and download JKBOSE Class 10 Result 2026Server load management and alternative accessOn the day of results, high traffic was recorded on the official portals, prompting the board to maintain dual website access and constant monitoring to ensure uninterrupted availability of results for students in Jammu and Kashmir.SMS-based result delivery was activated to assist candidates unable to access the internet, thereby ensuring roll number-based retrieval through a standard message format on the specified number.After the declaration of results, students proceed for admission to Class 11 in Science, Commerce or Arts streams depending on the eligibility and institutional requirements.Admission preparation and document handlingStudents are advised to keep the printed mark sheet and supporting documents like admit card with them for the counseling and admission processes. Institutions may require verification of roll number, registration number and subject-wise performance during the enrollment processes. All records remain subject to institutional verification during admission formalities as per Board guidelines, thereby ensuring completion of higher secondary admissions without delays or discrepancies in affiliated institutions in Jammu and Kashmir.